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  • The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) of more than 27, given that they also experience weight-related medical issues such as Tupe2 diabestes, high-cholesterol and/or hypertension (hypertension).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder in addition to being an aid to smoking cessation treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle including a reduced-calorie dieting and exercise, Contrave provides another treatment option for chronic weight reduction for people who are obese or are overweight and still have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes showed that patients had a normal weight loss of four years old.1% as opposed to participants have been given placebos) within a 12- month period, while an outside study involving patients with diabetes had the average weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to shed pounds can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you should err on the side of caution and allow FDA do its job and demand some investigation be done in order that the public is aware of the side effects and hazards of the medications before we take them. Keep in mind that drug companies will be in business to make money and that they would say everything to keep people on the medications.

    Researchers discovered that participants using this drug to get a year, lost weight within four weeks and have kept the extra weight off during the entire 56 weeks from the study. Contrave is often a combination from the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more efficient and safer.

    Combo-pilling is the newest fad or even better the newest into the future under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that by right now there are no long term prescription slimming capsules that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be authorized by the FDA.

    Seizures are a side effect with Contrave and must not be taken in people with seizure disorders. The drug could also raise blood pressure levels and heartrate, and really should not be used in individuals with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure and heartbeat and must stop used in patients with uncontrolled high blood pressure level, as well as by a person with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

    The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

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