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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) greater than 27, provided that they also experience weight-related health concerns such as Tupe2 diabestes, high cholesterol and/or hypertension (hypertension).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder in addition to being an aid to stop smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle including a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes established that patients had the average weight loss of four.1% rather than participants have been given placebos) within a 12- month period, while another study involving patients with diabetes type 2 had a normal weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to lose weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with fat loss and the people who go through it you ought to err along the side of caution and allow the FDA do its job and demand some investigation be done in order that the public recognizes the side effects and hazards of the medications before we bring them. Keep in mind that drug companies will be in business to make money and that they would say almost anything to keep people on their own medications.

    Researchers discovered that participants using this drug to get a year, dropped a few pounds within four weeks and have kept the body weight off through the 56 weeks in the study. Contrave is a combination with the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which are made up of several active ingredient, which may make them more potent and safer.

    Combo-pilling will be the newest fad or better yet the newest ahead under scrutiny and for that reason it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular is the fact that since right now there aren't any long term prescription diet pills that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be authorized by the FDA.

    Seizures really are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug could also raise blood pressure and heart rate, and must not be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high hypertension, as well as by a person with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients for the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

    The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

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