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  • Evidence is increasing that all addiction without exception is related to issues with the brain's reward center, particularly the mesolimbic system. This the main problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to lose weight can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight loss and the people who go through it you should err to the side of caution and permit the FDA do its job and demand some investigation be done so your public knows the side effects and risks of the medications before we drive them. Keep in mind that drug companies have been in business to make money and that they would say everything to keep people on his or her medications.

    Researchers discovered that participants investing in this drug for a year, dropped a few pounds within 4 weeks and have kept the weight off during the entire 56 weeks of the study. Contrave is often a combination with the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, which may make them more effective and safer.

    Combo-pilling will be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that at the time of right now there are no long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be licensed by the FDA.

    Seizures can be a side effect with Contrave and really should not be taken in people with seizure disorders. The drug may also raise blood pressure and heart rate, and must not be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and heart rate and must 't be used in patients with uncontrolled high blood pressure level, along with by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

    The most common effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

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