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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) greater than 27, provided they also suffer from weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stop smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle including a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight reduction for people who are obese or are overweight and have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had the average weight loss of four years old.1% rather than participants who were given placebos) throughout a 12- month period, while an outside study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at 12 months.

    Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight reduction and the people who go through it one should err assisting caution and allow the FDA do its job and demand some research be done in order that the public understands the side effects and perils associated with the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say almost anything to keep people on his or her medications.

    Researchers found out that participants investing in this drug for the year, dropped a few pounds within four weeks and have kept the weight off through the 56 weeks with the study. Contrave is really a combination in the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more potent and safer.

    Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular could be the fact that at the time of right now there are not any long term prescription diet pills that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug may also raise hypertension and pulse rate, and must not be used in those with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must stop used in patients with uncontrolled high blood pressure levels, along with by a person with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

    New UCLA study on smokers with mental, drug, and alcohol problems

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