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  • Evidence is increasing that all addiction without exception is related to difficulty with the brain's reward center, particularly the mesolimbic system. This area of the problem regulates reward responses in acquiring food and sex, plus nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both whenever they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to lose weight can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you should err along the side of caution and permit the FDA do its job and demand some study be done so that the public understands the side effects and hazards of the medications before we drive them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on the medications.

    Researchers found out that participants investing in this drug for any year, lost excess weight within a month and have kept the body weight off through the 56 weeks in the study. Contrave can be a combination from the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, that might make them more efficient and safer.

    Combo-pilling will be the newest fad or better yet the newest to come under scrutiny and therefore it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that as of right now there are no long term prescription diet pills that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA.

    Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug can also raise blood pressure levels and heart rate, and must not be used in individuals with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure and heart rate and must 't be used in patients with uncontrolled high blood pressure levels, as well as by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients for the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

    From a psychiatric viewpoint, evidence shows that the ordinary neural mechanism for goal-directed behavior may be hijacked from the addiction, and malfunctions in such a way that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus and the person engages in a "goal-directed behavioral response" that creates a "natural high"(Bostwick & Bucci, 2008).

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